Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning

By T. Nakashiba, J. Z. Young, T. McHugh, D. Buhl, S. Tonegawa. 2008

507 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Recent studies suggest that the monosynaptic pathway (entorhinal cortex–CA1–entorhinal cortex) is sufficient for MWM learning under certain condition”
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain (2009, background): “and ablating or inhibiting activity of specific neuronal population”
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss (2009, methodology): “…Dox was removed from the diet at weaning for a period of 2 to 8 weeks (average of 4 weeks without Dox) to ensure that Dox dissipated from the body (Nakashiba et al., 2008), and comparisons were performed between wild-type and dnSNARE mice, assuring that the only variable between these animals was…”
Circuits controlling vertebrate locomotion: moving in a new direction (2009, background): “Moreover, the spatial and temporal expression of these channels in vertebrate systems can be further refined with the use of intersectional approaches and tetracycline inducible promoter”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “…an associative learning between a chamber (context) and electrical footshocks that take place in that chamber, which requires the amygdala and the HPC including the trisynaptic pathway (Entorhinal cortex-DG-CA3-CA1) (Kim et al., 1993; Nakashiba et al., 2008; Phillips and LeDoux, 1992) (Figure 2).”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, background): “However, as the signiﬁcance of the direct connections between the cortex and other hippocampal subregions becomes clear, questions are being raised regarding how the DG actually contributes to hippocampal function (Brun et al. , 2008; Nakashiba et al. , 2008).”
Cell type-specific genetic and optogenetic tools reveal novel hippocampal CA2 circuits (2013, unknown): “5 and 6).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “Complete lesions of the dentate gyrus produce substantial impairment in water maze acquisition (Xavier et al. 1999) as do lesions that disconnect CA3 from CA1 (Brun et al. 2002; but see Nakashiba et al. 2008 ).”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “Behavioral effects in these tasks have also been demonstrated from specific genetic perturbations of other components of the dentate gyrus/CA3 network (McHugh et al., 2007; Nakashiba et al., 2008), suggesting that young neurons have a role consistent with the overall function of this intrinsic hippo”
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. (2012, unknown): “Rapid Pattern Completion-Mediated Contextual Recall Is Impaired in DG-TeTX Mice The pre-exposure-dependent contextual fear conditioning paradigm (Fanselow, 1986, 1990) has been used previously to test a rodent’s ability to carry out pattern completion-based memory recall (Matus-Amat et al., 2004; Na”
Computational influence of adult neurogenesis on memory encoding. (2009, unknown): “…memory tasks, combined with the observation that the DG may only be required for certain hippocampusdependent behaviors (McHugh et al., 2007; Nakashiba et al., 2008), suggests that neurogenesis may not be critical to many of the functions that the hippocampus has classically been assigned .”
Rewarded Outcomes Enhance Reactivation of Experience in the Hippocampus (2009, unknown): “, 2006; Cheng and Frank, 2008) and are thought to be important for spatial learning and memory formation (Redish and Touretzky, 1998; Redish, 1999; Samsonovich and Ascoli, 2005; Nakashiba et al., 2008).”
Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events (2015, background): “the hippocampal CA3 cells (Nakashiba et al. 2008) was specifically blocked by TeTX were normal in trace fear conditioning (Suh et al.”
Hippocampal CA3 Output is Crucial for Ripple-Associated Reactivation and Consolidation of Memory (2009, unknown): “…established that in the CA3-TeTX transgenic mice CA3 output is normal while the animals are raised on a diet containing doxycycline (Dox), but becomes blocked following Dox withdrawal without the converging output to CA1 from the temporoammonic (TA) axons being affected (Nakashiba et al., 2008).”