Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐ and antiinflammatory stimuli

By C. Buechler, M. Ritter, E. Orso, T. Langmann, J. Klucken, G. Schmitz. Journal of Leukocyte Biology, 2000

745 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients (2012, background): “CD163 is a highly specific monocyte/macrophage marker that has recently been suggested to be expressed primarily by the anti-inflammatory subtypes of macrophages [4-7,25].”
Role of Kupffer cells in host defense and liver disease (2006, background): “An increase of ED2 expression could be demonstrated by glucocorticoides and other anti-inflammatory mediators such as IL-10 and IL-6 while pro-inflammatory mediators like lipopolysaccharide (LPS), interferon-g (IFN-g) and TNF-a, suppress CD163 expression (19).”
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells (2002, neutral): “anti-inflammatory mediators and GC (23, 24).”
Microglial M1/M2 polarization and metabolic states (2016, background): “For example, CD163 is considered a M2-specific marker (Buechler et al., 2000); yet, differential expression of CD163 has not been observed in human disease (Barros et al., 2013) or polarized macrophages (Kittan et al., 2013).”
Macrophage phenotypes during tissue repair (2013, background): “Additionally, in freshly isolated human peritoneal Mp, cell-surface expression of CD206 or the M2c marker CD163 does not correlate with expression of the M2-associated genes TGF- , CCL18, or matrix metalloproteinase 9 [53].”