Out-of-Africa migration and Neolithic co-expansion of Mycobacterium tuberculosis with modern humans
By Iñaki Comas, M. Coscollá, Tao Luo, S. Borrell, Kathryn E. Holt, M. Kato-Maeda, Julian Parkhill, Bijaya Malla, S. Berg, G. Thwaites and 12 more. Nature Genetics, 2013
996 citations recorded by the source corpus.
Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
Subfields: Genetics, Infectious Diseases, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/36b5af7c4dc6f3fb116248d20e451225b7b3a82c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Public Health, Environmental and Occupational Health
Citations in the corpus
- The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes (2014, methodology): “We downloaded and assembled sequencing data from a recently published study of M. tuberculosis [98].”
- Toward a Phage Cocktail for Tuberculosis: Susceptibility and Tuberculocidal Action of Mycobacteriophages against Diverse Mycobacterium tuberculosis Strains (2021, background): “and tuberculosis-like infections in humans and animals and likely diverged from a common ancestor in Africa during the Neolithic age (24).”
- Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement (2014, neutral): “drugs [1–4].”
- MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization (2019, methodology): “In addition to its importance in biodiversity monitoring, mitochondrial genome also records maternal inheritance information and is extensively utilized to infer phylogenetic relationship between diverse lineages (1,16).”
- One chromosome, one contig: complete microbial genomes from long-read sequencing and assembly. (2015, background): “reads a few hundred bases in length) that are either mapped to a reference genome [4] or computationally assembled as a draft genome, forgoing the manual finishing process that was previously standard [17].”