Kinesin and Dynein Move a Peroxisome in Vivo: A Tug-of-War or Coordinated Movement?

By C. Kural, Hwajin Kim, Sheyum Syed, Gohta Goshima, Vladimir Gelfand, P. Selvin. Science, 2005

617 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Cell Biology

View Paper: https://www.semanticscholar.org/paper/36b246ec4692d5f00970542eb12d6839e71e784f

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In Cardiology and Cardiovascular Medicine

In Cell Biology

Citations in the corpus

The axonal transport of mitochondria (2005, background): “However, for neurofilament transport in axons and in a variety of other transport processes, anterograde movement driven by kinesin-1 is dependent on dynein (Ally et al., 2009; Kural et al., 2005; Ling et al., 2004; Uchida et al., 2009).”
Molecular motor traffic: From biological nanomachines to macroscopic transport (2006, background): “This cargo transport is typically performed by several motor molecules as revealed by electron microscopy [64,65] and single particle tracking [66–69].”
A BIRD’S EYE VIEW: TRACKING SLOW NANOMETER-SCALE MOVEMENTS OF SINGLE MOLECULAR NANO-ASSEMBLIES (2010, neutral): “Biological motor proteins have velocities on the order of 1 mm/s in vitro under saturating ATP conditions (King and Schroer, 2000; Kural et al., 2005; Nishiura et al., 2004), while these synthetic nanowalkers are limited by the kinetics of unwinding one DNA duplex and forming another, both 15–50 bas”
Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. (2006, background): “It was notable that although forward and reverse runs were often separated by pauses, rapid direction switching did occur, consistent with the idea that individual organelles can simultaneously bind both plus-end and minus-end motors (Hollenbeck, 1996; Welte et al., 1998; Kural et al., 2005).”
SINGLE-PARTICLE TRACKING (2009, methodology): “The Selvin group [110] measured the motion of kinesin and dynein motors in cultured Drosophila cells using several of these tricks.”
Neurofilaments and Neurofilament Proteins in Health and Disease (2017, background): “…(Mitchell and Lee 2009), consistent with evidence that the average velocity of gliding MTs can transition from slow to fast, depending on the number of active motors engaged (Scharrel et al. 2014), and that larger organelle cargoes require multiple motors for fast transport (Kural et al. 2005).”
Stochastic models of intracellular transport (2013, background): “One possibility is that the motors interact through a tug–of–war competition, where individual motors influence each other through the force they exert on the cargo (Hendricks et al., 2010; Kural et al., 2005; Muller et al., 2008a,b; Soppina et al., 2009; Welte, 2004), see Sec.”
Single-molecule analysis of dynein processivity and stepping behavior. (2006, background): “Another study has reported an 8 nm step size of cytoplasmic dynein carrying peroxisomes in living cells (Kural et al., 2005).”