FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition.

By M. Cross, L. Claesson‐Welsh. TIPS - Trends in Pharmacological Sciences, 2001

1,031 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/36957779e8b3b9a68744000186b7a77a252426de

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Citations in the corpus

• FGF/FGFR signaling in health and disease (2020, background): “Activation of FGFR1 or FGFR2 has been demonstrated to have a positive effect on vascular endothelial proliferation.(461) One important step of angiogenesis is extracellular matrix degradation.”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “FGF signaling (for review, see Cross and Claesson-Welsh 2001) appears to contribute to mitogenesis and angiogenesis of PDAC.”
• Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. (2016, background): “Basic fibroblast growth factor (bFGF) is another factor that plays multiple roles in the initiation of angiogenesis by promoting the migration, proliferation, and differentiation of endothelial cells [86].”
• Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. (2005, background): “FGFR engagement involves the activation of several parallel signaling pathways as a consequence of receptor autophosphorylation followed by recruitment of Shc, FRS2, and Crk adaptor molecules (for a review see [16]).”
• The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (2003, background): “These gene families include tumor necrosis factors (Flavell 2002), growth factors (Hackel et al. 1999; Cross and Claesson-Welsh 2001; Ornitz and Itoh 2001; Danielsen and Maihle 2002), cytokines (Schooltink and Rose-John 2002), chemokines (Onuffer and Horuk 2002), interferons (Grandvaux et al. 2002”
• An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “VEGF and FGF, the most potent angiogenic growth factors, are required for neoangiogenesis during embryogenesis and adulthood (Cross and Claesson-Welsh, 2001).”
• FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development (2007, background): “However, phylogenetic analysis using a large set of sea urchin RTKs and FGFRs from various species indicated that the tyrosine kinase domain of FGFR2 is divergent compared with that of other FGFRs (see Fig.”
• Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “Platelets have long been identified as a major source of vascular endothelial growth factor (VEGF),(64,65) platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF), each promoting tumor growth.(66,67) Activation of platelets and release of platelet microparticles leads to the”