Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

By D. Schmid, M. Pypaert, C. Münz. Immunity, 2007

725 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3690d59109ddacaf61408c04e8a4ac25ff74c840

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Beth Levine
2. H. J. Zeh
3. D. Tang
4. R. Kang
5. Judy H. Cho
6. N. Mizushima
7. V. Deretic
8. Simon R. Carding

In Molecular Biology

1. D. Klionsky
2. Beth Levine
3. N. Mizushima
4. Guido Kroemer
5. D. Tang
6. V. Deretic
7. R. Kang
8. Alec C. Kimmelman

In Oncology

1. Jennifer Lippincott-Schwartz
2. C. López‐Otín
3. P. Bonaldo
4. Beth Levine
5. R. Kang
6. Guillermo Mariño
7. Eric H. Baehrecke
8. D. Klionsky

Citations in the corpus

• Toll‐like receptors control autophagy (2008, background): “All eukaryotic cells from yeast to man are capable of undergoing autophagy, and most cells in the human body can activate this process (Levine and Klionsky, 2004) or even undergo a considerable level of constitutive autophagy (Schmid et al, 2007).”
• Unveiling the roles of autophagy in innate and adaptive immunity (2007, background): “observed constitutive autophagosome formation in MHC-class-II-positive cells, including B cells, dendritic cells and epithelial cell”
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “For some primary cells, delivering GFP-LC3 to precursor cells by infection with recombinant lentivirus, retrovirus or adenovirus,(331) and subsequent differentiation into the cell type of interest, is a powerful alternative to transfection of the already differentiated cell type.(74)”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Conventional DCs demonstrate high levels of basal autophagy, and afford very little or no induction of autophagy on stimulation with other types of immunological agonists or TLR signals (146, 181).”
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease (2008, methodology): “The HeLa cell line stably expressing LC3-GFP (HeLa LC3-GFP) was generated by lentiviral transduction as previously describe”
• Autophagy, Immunity, and Microbial Adaptations (2009, background): “…et al., 2007), (4) cooperation between immunity related GTPases and autophagy or Atg factors in attacking parasitophorous vacuoles (Gutierrez et al., 2004; Ling et al., 2006; Singh et al., 2006; Zhao et al., 2008), and (5) enhanced antigen presentation (Schmid et al., 2007; English et al., 2009).”
• NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation (2010, background): “Autophagy has been shown to have a major role in antigen presentation, with constitutive fusion of autophagosomes with multivesicular MHC class II–loading compartments in antigen-presenting cell”