Gene Ontology Consortium: going forward

By Judith A. Blake, Kim M Rutherford, J. Chan, R. Kishore, P. Sternberg, K. V. Auken, Hans-Michael Müller, J. Done, Yanhong Li. 2014

3,214 citations recorded by the source corpus.

The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community. The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes. We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions. The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data. Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser. We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology.

Subfields: Molecular Biology

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In Molecular Biology

Citations in the corpus

Clustering huge protein sequence sets in linear time (2017, methodology): “We assess Gene Ontology (GO) annotations [17] (Fig.”
DGIdb 3.0: a redesign and expansion of the drug–gene interaction database (2017, background): “Similarly, druggable genome genes are genes listed in the DGIdb “druggable genome” gene category (8, 11, 13, 15–19).”