TNF receptor subtype signalling: differences and cellular consequences.

By D. MacEwan. Cellular Signalling, 2002

659 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/365b7a2f09e3b7a6248f36c509f44c3a63f32126

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Moalem-Taylor
2. Bernhard T. Baune
3. Jaswinder K. Sethi
4. P. Austin
5. J. Mcafoose
6. W. Cawthorn

In Immunology

1. K. Futosi
2. Szabina Fodor
3. G. Moalem-Taylor
4. Bernhard T. Baune
5. Jaswinder K. Sethi
6. P. Austin
7. A. Mócsai
8. J. Mcafoose

In Oncology

1. G. Moalem-Taylor
2. Bernhard T. Baune
3. Jaswinder K. Sethi
4. P. Austin
5. A. Mócsai
6. J. Mcafoose
7. W. Cawthorn

Citations in the corpus

• TNF-α and adipocyte biology (2007, background): “Although TNFR1 and TNFR2 are highly homologous in their ligand-binding extracellular domains, their intracellular domains exhibit no sequence homology and they activate divergent signalling pathways [42].”
• Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “Themonomers of TNFα associate at the plasmamembrane as non-covalent trimers [27, 28] prior to being cleaved by the metalloprotease, TNFα converting en-”
• The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. (2010, positive): “TNF elicits its effects through two distinct receptors, the constitutively expressed TNFR1, which when activated results in receptor internalisation, and the inducibly expressed TNFR2, which on activation results in shedding of the receptor–ligand complex (MacEwan, 2002).”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “TNF-receptors trigger intracellular signaling by recruiting adapter proteins to the receptor complex [170,171].”
• Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “Zinc deficiency is increasingly associated with mental lethargy, cognitive impairment, symptoms of depression, and Alzheimer&s disease (Adlard and Bush 2011; Szewczyk et al. 2011a, b; Gower-Winter and Levenson 2012; Maes et al. 2012; Młyniec et al. 2014, 2015b, 2015).”
• Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity (2014, neutral): “[28] D.”
• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “The cytokine has the ability to bind to the two isotypes of membrane receptors located on the surface of almost every nucleated cell TNF-R1 (p55, CD120a, and TNFRSF1a) and TNF-R2 (p75, CD120b, and TNFRSF1b) [52, 53].”
• Evidence for a cytokine model of cognitive function. (2009, background): “Often referred to as TNF-R1 and TNF-R2 respectively, these two distinct receptors have been shown to elicit different molecular and cellular responses (Baud and Karin, 2001; Chen and Goeddel, 2002; MacEwan, 2002a,b; Wajant et al., 2003).”