Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

By S. Borgland, S. Taha, Federica Sarti, H. Fields, A. Bonci. Neuron, 2006

725 citations recorded by the source corpus.

Subfields: Cell Biology, Cognitive Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/35e9a07f42e940416ec2cf1da1e1e2c182801829

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Citations in the corpus

Timing to perfection: the biology of central and peripheral circadian clocks. (2012, methodology): “In addition, the peptide neurotransmitter orexin, which is expressed in a subset of neurons in the lateral hypothalamus (LH) that have projections to the VTA, is also implicated in mediating drug-induced activation of dopaminergic neurons in the VTA (Borgland et al., 2006).”
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “Indeed, the increase in the AMPAR/NMDAR ratio following in vivo cocaine administration was blocked when an OXR1 antagonist was administered systemically before the cocaine injection (Borgland et al., 2006).”
About sleep's role in memory. (2013, background): “The wake-promoting neuropeptide orexin robustly facilitated LTP induction in the ventral tegmental area (VTA) and in the hippocampus, directly and via LC noradrenergic release, respectively (115, 1296).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “For example, orexin afferents from the hypothalamus (Fadel et al, 2002) mediate an importance influence on reward behaviors (Harris et al, 2005) and synaptic plasticity (Borgland et al, 2006) presumably by excitatory actions on DA cells (Korotkova et al, 2003).”
Synaptic plasticity and addiction (2007, background): “Brief (5 minute) exposure to orexin A in slices rapidly and transiently enhanced NMDAR-mediated EPSCs (but not AMPAR-mediated EPSCs) in VTA DA neurons; this effect was blocked by the OXR1 antagonist, SB 334867 (Re”
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders (2007, background): “Acute cocaine injection enhances NMDA EPSCs at glutamatergic synapses onto VTA dopamine neurons by promoting the rapid insertion of primarily NR2A-containing NMDARs, a mechanism thought to underlie behavioural sensitizatio”
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness (2007, background): “Recent work has provided interesting insights into the cellular and molecular mechanisms underlying these effects by showing that orexin A input to the VTA potentiates NMDAR ( N -methyl- D -aspartate receptor)-mediated neurotransmission through a protein kinase C-dependent insertion of NMDARs in VTA”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “…excitatory transmission onto dopamine cells in the VTA elicited by repeated cocaine administration (Pu et al, 2006), and along with orexin release (Borgland et al, 2006), could contribute to the exciting series of observations of potentiated LTP in VTA dopamine cells following a single…”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, neutral): “regulate NMDARs in DA and other neurons (Borgland et al., 2006; Jia et al., 1998; Kwon and Castillo, 2008; Liao et al., 2001; Skeberdis et al., 2006; Ungless et al., 2003).”