Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds

By W. Aird. Circulation Research, 2007

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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “One subset of blood endothelial cells expressed high levels of the atypical chemokine receptor 1 (ACKR1) and adhesion molecules SELE (E-selectin) and SELP (P-selectin) and was annotated as activated endothelial cells (Aird, 2007).”
The Endothelium and Its Role in Regulating Vascular Tone (2010, background): “Efficiency of diffusion is further enhanced by the slow bloodflow which helps to increase the time available for diffusion [12].”
The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “VSMC myosin fibers regulate blood flow via vasoconstriction and vasodilation (Aird, 2007).”
Endothelial cell control of thrombosis (2015, background): “Microvascular endothelial cells also possess extensive phenotypic heterogeneity depending on their location [17].”
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “ECs from different anatomical locations demonstrate a remarkable heterogeneity in both structure and function under normal and pathological conditions (5, 6).”