The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion

By Jizong Gao, J. Dennis, R. Muzic, M. Lundberg, A. Caplan. Cells Tissues Organs, 2001

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Aging of mesenchymal stem cells. (2006, background): “MSC will populate a wide variety of tissues after systemic infusion (Gao et al., 2001).”
Mesenchymal stem cell homing: the devil is in the details. (2009, positive): “Gao et al. also found that MSCs gradually moved from the lung to the liver, spleen, kidney, and bone marrow (Gao et al., 2001a).”
Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect (2009, background): “In rodents, intravenously injected MSCs or peripheral blood stem cells (PBSCs) accumulated initially in the lungs, and gradually moved to liver, spleen, kidney, and bone marrow within 48 h [9,10].”
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 (2009, background): “As expected (Gao et al., 2001; Schrepfer et al., 2007; Lee et al., 2009), most of the cells cleared from the circulation were trapped in the lung.”