Oncogenic PI3K deregulates transcription and translation

By A. Bader, Sohye Kang, Li Zhao, P. Vogt. Nature Reviews. Cancer, 2005

817 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/352fddaa2129b6d35926ad01827fadbdc6fd393f

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Citations in the corpus

Hyperactive Ras in developmental disorders and cancer (2007, background): “PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-triphosphate, which activates downstream kinases such as 3-phosphoinositide-dependent protein kinase 1 ( PDK1 ) and Ak”
Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “Mutations are also found in more than 30% of solid tumors including colorectal, gastric, brain, breast, certain brain tumors, ovarian, lung, and hepatocellular carcinomas [133,152].”
Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer (2009, background): “gif" NDATA ITEM> ]> Since its discovery in the 1980s, the family of lipid kinases termed phosphoinositide 3-kinases (PI3Ks) has been found to have key regulatory roles in many cellular processes, including cell survival, proliferation and differentiatio”
Ras, PI(3)K and mTOR signalling controls tumour cell growth (2006, background): “Recent pharmaceutical efforts in developing kinase inhibitors have resulted in a number of agents designed to inhibit the kinase components of these signalling pathways (mTOR, PI(3)K, RTKs, Raf and AKT).”
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? (2022, background): “After being stimulated, PI3K-110a transforms its lipid substrate phosphatidylinositol-4,5bisphosphate (PIP2) to phosphatidylinositol- 3,4,5-bisphosphate (PIP3), triggering the AKT/mTOR pathway (19).”
Comprehensive genomic characterization defines human glioblastoma genes and core pathways (2008, neutral): “Gibbs(34), Joe Gray(28), Raju Kucherlapati(22), Marc Ladanyi(27), Eric Lander(4,60,61), Richard M.”
The emerging roles of forkhead box (Fox) proteins in cancer (2007, background): “Deregulation of these kinases is frequently observed in tumours and can contribute significantly to tumorigenesis by promoting the nuclear export and/or proteosomal degradation of FoxO (reviewed in (Ref”
The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “, 2005b), providing support to the hypothesis that alteration of PI3K signaling at multiple levels can result in cancer (Bader et al., 2005).”