Hyperactive Ras in developmental disorders and cancer

By Suzanne Schubbert, K. Shannon, G. Bollag. Nature Reviews. Cancer, 2007

649 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7e5b0b4ec4b51535dc60cf958b59f5260876ac97

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In Molecular Biology

1. S. Richard
2. Kai-Wei Chang

Citations in the corpus

• Germline gain-of-function mutations in SOS1 cause Noonan syndrome (2007, background): “Constitutive activation of this pathway as a result of mutations is considered a key event in the development of several human malignancies and developmental disorder”
• RNA-binding proteins in human genetic disease. (2008, positive): “For example, epidermal growth factor receptor 2 (HER2) gene amplification is frequently observed in breast cancer [64], and activating mutations in the RAS oncogene are highly prevalent in colon cancer [ 65 ].”