Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex.

By Daniel Durstewitz, Jeremy K. Seamans, Terrence J. Sejnowski. Journal of Neurophysiology, 2000

626 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/35287d52756ca61afce8f6d7c4629c8f35dce0e2

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Interactions between frontal cortex and basal ganglia in working memory: A computational model (2001, methodology): “These mechanisms take advantage of the properties of the NMDA receptor, which is activated both by synaptic input and by postsynaptic neuron depolarization and produces excitation through Ca 2+ ions (Durstewitz, Kelc, & Gunturkun, 1999; Durstewitz, Seamans, & Sejnowski, 2000a; Fellous et al., 1998”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “Second, working memory may be impaired because persistent activity cannot be stably maintained by fast AMPA receptor-mediated excitation alone (182, 259, 800, 939, 1023, 1029, 1030).”
Mental fatigue: costs and benefits. (2008, background): “DA may be involved in sustaining PFC activity over longer periods of time, enabling us to persist toward goals, protecting our goal relevant task representations from disruption by irrelevant, distracting information (Durstewitz et al., 1999, 2000).”
From cognitive to neural models of working memory (2007, background): “Such interactions could support working memory maintenance processes via synaptic reverberations in recurrent circuits (Durstewitz et al. 2000b; Wang 2001) or synchronous oscillations between neuronal populations (Singer & Gray 1995; Engel et al. 2001).”
MUC (Memory, Unification, Control) and beyond (2013, background): “These will respond with a self-sustaining firing pattern (see Durstewitz et al., 2000, for a review).”
An integrative theory of prefrontal cortex function. (2001, background): “A similar role for DA in the PFC has been suggested by Durstewitz et al (1999, 2000).”
Multilevel structure in behaviour and in the brain: a model of Fuster's hierarchy (2007, background): “In particular, the PFC has been proposed to have ion channel properties, recurrent connectivity and a neuromodulatory environment conferring on it a special capacity to store information over time and in the face of distraction (Lisman et al. 1998; O’Reilly et al. 1999; Durstewitz et al. 2000; O’Rei”
FROM REINFORCEMENT LEARNING MODELS OF THE BASAL GANGLIA TO THE PATHOPHYSIOLOGY OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS (2011, background): “Biophysically realistic neurocomputational models suggest that dopamine stabilizes representations in PF”
Dopamine and Cognitive Control in Prefrontal Cortex. (2019, methodology): “Importantly, these networks allow investigation of the potential mechanisms of dopamine action by changing synaptic conductances [142,145].”