The nuclear factor NF-kappaB pathway in inflammation.

By T. Lawrence. Cold Spring Harbor Perspectives in Biology, 2009

4,528 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/34fa2f4ec751a302329ac952048fbfe3c84c9ebd

How researchers see this paper

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In Cancer Research

1. Danyang Li
2. Minghua Wu
3. Wenshuai Wang
4. Anna Marie Pyle

In Immunology

1. Danyang Li
2. Minghua Wu
3. Alberico L. Catapano
4. Wenshuai Wang
5. Anna Marie Pyle

In Oncology

1. Danyang Li
2. Minghua Wu

Citations in the corpus

• Pattern recognition receptors in health and diseases (2021, background): “The NF-κB signaling The transcription factor NF-κB is named after it was first discovered to be involved in the transcription of B cell κ chain genes.(250) NF-κB is a heterodimer composed of two molecules, p50 and p65, and is inactive due to binding to the inhibitory protein IκB under normal conditi”
• LOX-1, OxLDL, and Atherosclerosis (2013, background): “Anti-LOX-1 monoclonal antibody reduces superoxide formation and increases intracellular NO level, suggesting the involvement of LOX-1 in these OxLDL-induced effects [28].”
• Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “Recently, it has become very clear that there are two separate NF-κB activation pathways: the classical pathway and the alternative pathway [76,77].”
• Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “…(e.g., IL-1b, IL-6, IL-8, TNF-a, and MCP-1), chemokines, acute phase proteins (CRP and fibrinogen), matrix metalloproteinases (MMPs), adhesion molecules, growth factors, and other factors involved in inflammatory response, such as COX-2 and iNOS (Lawrence 2009; Ghosh and Hayden 2012; Prasad 2014a).”
• Nanomedicine-Driven Modulation of the Gut–Brain Axis: Innovative Approaches to Managing Chronic Inflammation in Alzheimer’s and Parkinson’s Disease (2025, unknown): “This metabolic remodeling impairs mitochondrial biogenesis and ATP synthesis, key requirements for effective neuronal repair [27].”