Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

By L. Zou, Stephen J. Elledge. Science, 2003

2,867 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/34c3e13fca055e6247e254e0f0e2e2572e9d08b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Bartek
2. Stephen P. Jackson
3. J. Lukas
4. Karlene A. Cimprich
5. T. de Lange
6. G. Ira

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. T. de Lange
5. Stephen J. Elledge
6. C. Lukas
7. Karlene A. Cimprich
8. J. R. Chapman

Citations in the corpus

• Homologous recombination and its regulation (2012, background): “Phosphorylation of RPA by these kinases is critical for Rad51 recruitment to DSB sites or for HR during replication stress (30,123).”
• ATR: An Essential Regulator of Genome Integrity (2008, neutral): “Most data suggest that this structure contains single-stranded DNA (ssDNA”
• Chk1 promotes replication fork progression by controlling replication initiation (2010, background): “ATR becomes activated by regions of singlestranded DNA at stalled replication forks (15) and activates Chk1 by phosphorylating it on Ser345 and Ser317 (16–18).”
• DNA helicases Sgs1 and BLM promote DNA double-strand break resection. (2008, background): “Antibodies The antibodies used in this study were rabbit -Rad53 (a gift from Noel Lowndes), goat -BLM (C18, Santa Cruz Biotechnologies), mouse -RPA2 (Ab1, 9HD, Lab Vision), rabbit -RPA pS4/S8 (Bethyl), rabbit - H2AX (Cell Signaling), rabbit -Chk2 pT68 (Cell Signaling), rabbit -Chk2 (Abcam), rabbit -”
• Continued primer synthesis at stalled replication forks contributes to checkpoint activation (2010, background): “This is accompanied by increased RPA recruitment to chromatin, which is thought to reflect the ssDNA that accumulates during unwinding (Michael et al., 2000; Mimura et al., 2000; Walter and Newport, 2000; Lupardus et al., 2002; Zou and Elledge, 2003).”
• The DNA Damage Response: Making it safe to play with knives (2010, background): “RPA-ssDNA complex recruits the ATR/ATRIP complex through direct interaction with ATRIP to localize it to the fork (Figure 1B) (Zou and Elledge, 2003).”
• Checking on DNA damage in S phase (2004, background): “Conversely, the enhanced backup activation of ATR — which has a constitutive, moderate activity — is local and delayed, and depends on prior processing of the DSB”
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis (2005, background): “, and increased amounts of the single-stranded-(ss)DNA-binding replication protein A (RPA”
• Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage (2005, background): “For example, recruitment of ATR to single-stranded DNA (ssDNA) requires ATRI”