Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.

By S. Brickley, S. Cull-Candy, M. Farrant. 1996

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. N. A. Cayco-Gajic
2. R. Silver
3. Guy O. Billings
4. Kanichay Rt
5. A. Lorincz
6. Ian Duguid
7. S. Brickley
8. K. Powell

Citations in the corpus

• Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Similarly, the large tonic GABAA receptor inhibitory conductance present in cerebellar granule cells (Brickley et al., 1996) ensures a high spike threshold (Hamann et al.”
• Properties of Somatosensory Synaptic Integration in Cerebellar Granule Cells In Vivo (2006, methodology): “…vitro studies, in which it has been suggested that the role of Golgi cell inhibition in granule cells is to set the excitability level on a longer time scale using a predominantly tonic form of inhibition (Brickley et al., 1996; Wall and Usowicz, 1997; Rossi and Hamann, 1998; Hamann et al., 2002).”
• Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene (2006, background): “The multiple ways in which GABAergic neurotransmission shapes neural activity can be attributed to two spatially and temporally unique modes of inhibition (Brickley et al., 1996; Wall and Usowicz, 1997; Mody, 2001; Farrant and Nusser, 2005).”
• Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning (2012, unknown): “In contrast to PCs, GCs responded to GABA with a slight depolarization that may cause a shunting inhibition (Brickley et al , 1996).”
• Shunting inhibition modulates neuronal gain during synaptic excitation. (2003, methodology): “We establish that tonic shunting inhibition reduces the gain of the f-F relation- steps in these (Brickley et al., 1996; Hamann et al., 2002) and other cells (Berman et al., 1992; Connors et al.,ship and elucidate the underlying biophysical mecha- nisms.”
• Cerebellar Golgi cells in the rat: receptive fields and timing of responses to facial stimulation (1999, background): “The strong tonic component of granule cell inhibition that was recently described in cerebellar slice preparations (Brickley et al., 1996; Wall & Usowicz, 1997) may contribute to the silent period.”
• Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding (2014, background): “…relatively high fixed threshold, since GCs typically require activation of three of their four MF inputs to fire (Jörntell and Ekerot, 2006; Schwartz et al., 2012) and spike threshold is dominated by the presence of a large tonic inhibitory conductance (Brickley et al., 1996; Duguid et al., 2012).”
• High Frequency Burst Firing of Granule Cells Ensures Transmission at the Parallel Fiber to Purkinje Cell Synapse at the Cost of Temporal Coding (2013, background): “This filter function probably results partly from Golgi cell inhibition (Brickley et al., 1996), but in principle additional filtering might occur at the PF-PC synapse.”
• Expression of Distinct α Subunits of GABAA Receptor Regulates Inhibitory Synaptic Strength (2004, unknown): “Our results indicate that the developmental changes of GABAAmediated current kinetics and amplitude reported in cerebellar granule neurons in slices (Brickley et al. 1996; Tia et al. 1996; Vicini et al. 2001) can be observed in primary cultures of these neurons despite differences in synaptic connec”