Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction

By Nora D. Volkow, Gene-Jack Wang, Frank Telang, J. S. Fowler, Jean Logan, Anna Rose Childress, Millard Jayne, Yeming Ma, Christopher T. Wong. Journal of Neuroscience, 2006

1,166 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/342c8308f0fb0742e8d4ef5fc470f57c10af6e27

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Citations in the corpus

Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. (2008, positive): “Finally, the presentation of drug cues to human cocaine addicts not only induces drug craving that is correlated with activation of the amygdala and limbic prefrontal cortical areas (Grant et al., 1996; Childress et al., 1999; Garavan et al., 2000; Volkow et al., 2002), but also results in marked ac”
The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, background): “Indeed, cells in the dorsal striatum are progressively recruited during different types of learning from simple motor tasks to drug self-administration (Everitt and Robbins, 2005; Lehericy et al , 2005; Pasupathy and Miller, 2005; Porrino et al , 2004; Volkow et al , 2006).”
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology (2008, background): “…reductions in the specific binding of [ 11 C]raclopride) induced by the intravenous administration of stimulant drugs (MP or amphetamine) in cocaine abusers and alcoholics were markedly blunted when compared with controls (more than 50% lower; Volkow et al. 1997, 2007a; Martinez et al. 2005, 2007).”
Brain activities associated with gaming urge of online gaming addiction. (2009, background): “A previous study reported that dopamine change in dorsal striatum under craving response was associated with withdrawal symptoms (Volkow et al., 2006).”
Neurocircuitry of Addiction (2009, background): “As such, the dorsal striatum may be a fundamental component of addiction (Volkow et al, 2006).”
Cognitive Control of Drug Craving Inhibits Brain Reward Regions in Cocaine Abusers (2009, methodology): “Subjects were tested using a video of cocaine cues that was previously shown to induce the subjective report of craving and to increase objective measures of striatal DA in cocaine abusers (Volkow et al., 2006).”
Dissecting components of reward: ‘liking’, ‘wanting’, and learning (2009, result): “Generation of urges to act, perhaps involving blended motor and motivational functions within the neostriatum (a structure also known to participate in movement) seems consistent with several emerging lines of thought about basal ganglia function [52,53,54 ,55].”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “" (Volkow et al. 2006, p. 6583) and " addictive drugs activate brainreward mechanisms, most especially the meso-accumbens dopaminergic link, resulting in the 'hit', 'high', or 'blast' sought by human users of such drugs.”
Widespread reward-system activation in obese women in response to pictures of high-calorie foods (2008, positive): “The dorsal striatum appears to process rewarding action-outcomes and has been associated with habit learning and craving in addiction (O'Doherty, 2004; Volkow et al., 2006).”
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications (2004, background): “In human beings, PET studies with [(11)C]raclopride recently confirmed this hypothesis by showing that, in cocaine abusers, drug cues (cocaine-cue video of scenes of subjects taking cocaine) substantially increased DA in the dorsal striatum and that these increases were associated with cocaine cravi”
Addiction: Beyond dopamine reward circuitry (2011, background): “when they watched a cocaine-cue video (scenes of subjects procuring and smoking cocaine) (23).”
Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies (2011, positive): “, 2010), there is also evidence of dorsal striatal involvement in addictive behavior (McClernon et al., 2009; Volkow et al., 2006; Wilson et al., 2008).”