Molecular and cellular mechanisms of cadmium carcinogenesis.

By M. Waisberg, P. Joseph, B. Hale, D. Beyersmann. Toxicology, 2003

1,492 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/33ae5ea48b02dfd044680c5fa372671981adb169

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. E. Asuquo
2. A. Hartwig
3. S. Flora
4. A. Martin
5. Flor R. Siperstein
6. Petrus Nzerem
7. D. Beyersmann
8. Xiaolei Fan

In Nutrition and Dietetics

1. A. Hartwig
2. S. Flora
3. D. Beyersmann

Citations in the corpus

• Chelation in Metal Intoxication (2010, background): “ROS has been implicated in chronic Cd nephrotoxicity [170], immunotoxicity [171], and carcinogenesis [172].”
• Signaling responses in plants to heavy metal stress (2007, background): “malian cells ( Waisberg et al. 2003 ) non-reducing metals like Cd may enhance the genotoxicity by inhibition of DNA repair and methylation processes.”
• Cytotoxic and genotoxic potential of surface water from the Pitimbu river, northeastern/RN Brazil (2007, background): “…such as iron and copper can also cause indirect effects due to increased oxidative stress leading to cytotoxicity and DNA damage (Knasmuller et al., 1998; Steinkellner et al., 1998; Costa et al., 2002; Harris and Shi, 2003; Waisberg et al., 2003; Table 4 - Analysis of Pitimbu river surface water.”
• Metal contamination in urban, suburban, and country park soils of Hong Kong: a study based on GIS and multivariate statistics. (2006, background): “…their accumulation in the fatty tissues of the human body and affect the central nervous system, or the heavy metals may be deposited in the circulatory system and disrupt the normal functioning of the internal organs (Nriagu, 1988; Thompson et al., 1988; Waisberg et al., 2003; Bocca et al., 2004).”
• Cellular mechanisms of cadmium-induced toxicity: a review (2014, background): “These free ions participate in causing oxidative stress via the Fenton reactions (Casalino et al. 1997; Waisberg et al. 2003) (Figure 1).”
• Role of oxidative stress in cadmium toxicity and carcinogenesis (2009, neutral): “Minimal role of ROS in Cd-induced malignant transformation Cd-induced ROS is thought to be important in Cd carcinogenesis (Waisberg et al., 2003; Valko et al., 2006), either through oxidative stress or through the inhibition of oxidative DNA damage repair (Waisberg et al., 2003).”
• Cadmium stress: an oxidative challenge (2010, neutral): “Based on several similar studies, it has also been concluded that the protective effect of MT depends on the distribution of Cd, inducibility of MT genes, and finally the levels of MT in various tissues and species (Waisberg et al. 2003).”
• Adsorption of Cd(II) and Pb(II) ions from aqueous solutions using mesoporous activated carbon adsorbent: Equilibrium, kinetics and characterisation studies (2017, background): “Cadmium is released into the environment in a variety of ways such as tobacco smoking, mining, smelting and refining of non-ferrous metals; fossil fuel combustion, incineration of municipal waste (especially cadmium-containing batteries and plastics), metal plating industries, manufacture of phospha”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “In various cell types in vitro, cadmium evokes receptor-mediated release of the second messengers inositol-1,4,5-trisphosphate and calcium, it activates various mitogenic protein kinases, transcription and translation factors, and it induces the expression of cellular proto-oncogenes c-fos, c-myc an”