Novel injectable neutral solutions of chitosan form biodegradable gels in situ.

By A. Chenite, C. Chaput, D. Wang, C. Combes, M. Buschmann, C. Hoemann, J. Leroux, B. Atkinson, F. Binette, A. Selmani. Biomaterials, 2000

1,310 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/33a4b04c13f7203f9b49489b34b3d5964e20678b

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In Biomaterials

1. C. Jérôme
2. Florence Croisier
3. C. Pillai
4. C. P. Sharma
5. W. Paul
6. N. Acosta
7. I. Aranaz
8. J. Gunn

In Biomedical Engineering

1. J. Gunn
2. M. Rinaudo
3. C. Pillai
4. C. Jérôme
5. Florence Croisier
6. S. Hudson
7. C. P. Sharma
8. E. Gil

In Molecular Medicine

1. C. Jérôme
2. Florence Croisier
3. C. Pillai
4. C. P. Sharma
5. W. Paul
6. N. Acosta
7. I. Aranaz
8. M. Rinaudo

Citations in the corpus

• Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications (2015, background): “It should be noted that although the type of reaction between chitosan and polyol-phosphates is close to physical crosslinking, the nature of this interaction has not been clearly explained [27,116].”
• Functional Characterization of Chitin and Chitosan (2009, background): “However, the DD was pointed to as another factor that may be involved in the chelation ability of chitosans [108-181].”
• In situ forming implants - an attractive formulation principle for parenteral depot formulations. (2012, background): “The gel was capable of maintaining the bioactivity and releasing bone morphogenic protein (BMP) [72].”
• Chitin and chitosan: Properties and applications (2006, methodology): “Many chitosan hydrogels are obtained by treatment with multivalent anions: the case of glycerolphosphate is mentioned above [104], but oxalic acid has also been used [93b,184] as well as tripolyphosphate [185,186].”
• Stimuli-reponsive polymers and their bioconjugates (2004, background): “The complexation of two or more biopolymers [26,27], salt [83], or surfactant [87–89] can be controlled by stimulus such as temperature.”
• Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications (2008, neutral): “The addition of polyol salts has been used to enable encapsulation of cells at neutral pH, where gelation becomes temperature dependent.(96) Several approaches have explored methods to covalently crosslink chitosan to better control the macroscopic gel properties.”
• Chitosan-based hydrogels for controlled, localized drug delivery. (2010, background): “The mixture remains a clear liquid at room temperature and gels at 37 °C [78].”
• Chitosan-based biomaterials for tissue engineering (2013, background): “Thermo-sensitive chitosan hydrogels can be obtained by blending chitosan with polyol salts, as glycerol phosphate disodium salt [72].”
• Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. (2012, background): “Glycerol-phosphate salt can be added to the chitosan solution to help modulate electrostatic, hydrophobic, and hydrogen bonding interactions, culminating in the displacement of water upon heating followed by the gelation of chitosan molecules [79].”