Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC

By Daejong Jeon, Sangwoo Kim, M. Chetana, D. Jo, H. Ruley, Shih-Yao Lin, D. Rabah, J. Kinet, Hee-Sup Shin. Nature Neuroscience, 2010

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Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks. Observers had higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC) and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC-limited deletion of Cav1.2 Ca2+ channels in mice impaired observational fear learning and reduced behavioral pain responses. These results demonstrate the functional involvement of the affective pain system and Cav1.2 channels of the ACC in observational social fear.

Subfields: Behavioral Neuroscience, Cognitive Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/33769ebb2f77eea4c1fa35d68871c594d83c02dc

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Citations in the corpus

Neuronal voltage-gated calcium channels: structure, function, and dysfunction. (2014, background): “2 conditional knockouts do not learn from fearful stimuli, a behavior attributed to L-type channel function in the amygdala (Jeon et al., 2010; Langwieser et al., 2010).”
Merging second-person and first-person neuroscience (2013, neutral): “, Edwards & Potter 1992). Like Schilbach et al.’s focus on emotional engagement and social interaction, these approaches also emphasize interestbased, emotionally (and morally) loaded social interaction. Few would argue that an aim of Wittgenstein’s philosophy was to show that a dualist interpretati”
Assessing equine emotional state (2018, background): “It has been demonstrated (in mice) that observing other individuals suffering from aversive stimuli can result in fear and associated behavioural responses (Jeon et al., 2010).”
Central mechanisms of pathological pain (2010, background): “The ACC mediates key emotional-aversive aspects of pai”
The ecology of human fear: survival optimization and the nervous system (2015, methodology): “Mayberg et al. work has since been supported in rodents using optogenetic methods, thus further supporting the role of the vmPFC (including the sgACC) in the control of emotion (Covington et al., 2010).”
Social functioning in major depressive disorder. (2016, positive): “Since competition is often associated with social rewards but also with the fear of losing, high reactivity of the stress system, involving insula, amygdala and ACC, in response to fear of losing and social exclusion may explain competition avoidance in patients with depression (Dedovic et al., 2009”
Social dimension of emotions and its implication for animal welfare (2012, background): “, 2011) or investigated the involvement of different brain centres (Jeon et al., 2010).”