Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression1

By A. Gewirtz, T. Navas, Sean Lyons, P. Godowski, J. Madara. Journal of Immunology, 2001

1,446 citations recorded by the source corpus.

Subfields: Immunology, Molecular Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/33374dfc9515d8c118f11e4e79a2f75dc95ccde6

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In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Satoshi Uematsu
4. K. Takeda
5. Taro Kawai
6. T. Kaisho
7. O. Takeuchi
8. M. Abreu

Citations in the corpus

• TLR Signaling in the Gut in Health and Disease1 (2005, background): “1 RNA, protein (9) RNA (low level) (8) RNA (8) RNA (8) 2 * (9), (36) RNA, protein (92), RNA (5), poorly responsive to ligands (6, 8), RNA, ( protein) poorly responsive to ligands (8), protein (92) RNA, poorly responsive to ligands (8) 3 RNA, protein (9) ND RNA (92) RNA, not detectable at protein lev”
• The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (2003, background): “Flagellin, the structural component of bacterial flagella, is detected by Toll-like receptor-5, which mediates inflammatory responses to Salmonella (Gewirtz et al. 2001).”
• Toll-like receptors. (2003, background): “Furthermore, TLR5 is expressed exclusively on the basolateral surface of the intestinal epithelial cells (155).”
• Production of recombinant proteins in Escherichia coli (2004, neutral): “…properties of flagellin and the possibility of expressing heterologous peptides in a polymeric form render the flagellin expression fusion system especially suited for the development of vaccines against pathogenic microorganisms (Newton et al., 1991; Gewirtz et al., 2001; McSorley et al., 2002).”
• Toll-like receptors and innate immunity (2006, background): “[18] reported that TLR5 is expressed on the basolateral surface, but not the apical side of intestinal epithelial cells, suggesting that TLR5 serves as the sensor for the pathogenic bacteria that invade across the epithelium.”