Structural symmetry and protein function.

By David S. Goodsell, Arthur J. Olson. 2000

924 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

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Citations in the corpus

Hallucinating symmetric protein assemblies (2022, background): “Because of the many applications of cyclic protein oligomers, ranging from small molecule binding and catalysis to building blocks for nanocage assemblies (5), de novo design of such structures has been of considerable interest from the beginning of the protein design field”
Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions (2020, background): “Due to the reciprocity of inter-protomer contacts, dimeric interfaces can be readily stabilized, providing an expansive and stable platform to evolve diverse functions and regulatory circuits through cooperativity or allostery [1,4].”
Hallucinating protein assemblies (2022, background): “Because of the many applications of cyclic protein oligomers, ranging from small molecule binding and catalysis to building blocks for nanocage assemblies( 5 ), de novo design of such structures has been of considerable interest from the beginning of the protein design field ( 6 , 7 ).”
Computational Design of Self-Assembling Cyclic Protein Homo-oligomers (2016, methodology): “Analysis of the properties of the design models revealed that designs with (1) a high total charge (greater than –50), (2) small (<750 Å(2)) interfaces, (3) low shape complementarity (<0.”
Life is Physics: Evolution as a Collective Phenomenon Far From Equilibrium (2010, background): “Of the remainder, 59% were either dimers or tetramers, with a clear preference for even numbers of sub-units[154, 155].”
Computational design of a symmetric homodimer using β-strand assembly (2011, background): “Many protein–protein interfaces are built on the progression from a monomer to symmetric homodimer to asymmetric homodimer to heterodimer (24, 40).”
3D Complex: A Structural Classification of Protein Complexes (2006, background): “There have been studies on manually curated subsets that address issues such as evolution of oligomers [11,12], biochemical and geometric properties of protein complexes [13], or the assembly pathways in multisubunit proteins [14,15].”
HSYMDOCK: a docking web server for predicting the structure of protein homo-oligomers with Cn or Dn symmetry (2018, background): “A major subclass of protein–protein interactions is formed by symmetric homo-oligomers (17–19).”
Self-assembling protein nanoparticles in the design of vaccines (2015, neutral): “While many natural proteins have acquired self-assembling properties during evolution [13], the de novo engineering of protein assemblies is challenging.”