A microRNA expression signature of human solid tumors defines cancer gene targets

By Stefano Volinia, George A. Calin, Chang-Gong Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, Marilena V. Iorio, C. Roldo, M. Ferracin and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

6,046 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/32babc3cc6a29d844cdaa78974659fda76c4e035

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Citations in the corpus

MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “Global downregulation of miRNA expression is an emerging feature in cancer, and the specific deregulation of certain miRNAs is seen in specific tumour type”
microRNAs in cancer (2013, background): “Similar to miR-155, the miRNAs encoded by the miR-17/92 cluster are highly overexpressed in cancer and are located in a fragile site of the genome (38, 73).”
Widespread deregulation of microRNA expression in human prostate cancer (2008, methodology): “A number of studies have detected frequent alterations of miRNA expression in a variety of human malignancies (Lu et al., 2005; Volinia et al., 2006).”
Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth (2008, background): “Another study suggested that overexpression of miR-17-5p, miR-20a, miR-21, miR-92, miR-106a, and miR-155 could be considered an miRNA signature of solid cancer [59].”
Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening (2009, background): “Indeed, the miR-17-92 cluster first attracted attention following a series of observations linking these miRNAs to cancer pathogenesis.(23) 24 The oncogenic role of miR-17-92 cluster where miR-17 and miR-92 are located had been reported in other cancers such as lymphoma,(25) lung,(26) 27 and thyroid”
Roles of HMGA proteins in cancer (2007, result): “This result appears consistent with previously published data showing increased miR-181 expression in several malignant neoplasia”
Breast cancer intrinsic subtype classification, clinical use and future trends. (2015, background): “MiR-125b, miR-145, miR-21 and miR155 were reported to be the most dysregulated miRNAs in their study, and some of these malfunctional miRNAs were correlated with specific clinical features of breast tumors including the expression of hormone receptors, tumor stage, vascular invasion and proliferatio”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Besides being the most commonly overexpressed oncogenic miRNA among solid tumours with different origi”
MicroRNA signature predicts survival and relapse in lung cancer. (2008, methodology): “Recent reports even suggest that the expression profiling of microRNAs may be a more accurate method of classifying cancer subtype than using the expression profiles of protein-coding genes (Calin and Croce, 2006b; Volinia et al., 2006).”