Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

By H. Cohen, Siva Lavu, Kevin J. Bitterman, B. Hekking, Thomas A. Imahiyerobo, Christine Miller, Roy A. Frye, Hidde L. Ploegh, B. Kessler, D. Sinclair. Molecules and Cells, 2004

610 citations recorded by the source corpus.

Subfields: Literature and Literary Theory

View Paper: https://www.semanticscholar.org/paper/32ba57b5b763fbb31ae609eda8371dbec951ba51

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Citations in the corpus

Histone Deacetylase Inhibitors: Overview and Perspectives (2007, background): “IRS-1 ND (110) h-Catenin ND (111) DNA repair enzymes Ku70 ND (112) WRN ND (113) Nuclear import Importin-a7 ND (114)”
SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “In 1994, Takahashi and colleagues (62) identified the protein CLOCK as main regulator of the autonomous circadian rhythm in cells.”
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006, background): “When the cell is stressed, HATs acetylate Ku70, leading to dissociation of the complex and translocation of BAX to the mitochondria, where it activates the apoptotic programm”
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase (2004, background): “…European Molecular Biology Organization The EMBO Journal VOL 23 | NO 12 | 2004 EMBO THE JOURNAL 2369 non-histone substrates, including TAFI68, PCAF, p300, MyoD, p53, and Ku 70 (Luo et al, 2001; Muth et al, 2001; Vaziri et al, 2001; Fulco et al, 2003; Cohen et al, 2004; Motta et al, 2004).”
Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “DNA damage promotes Ku70 acetylation on multiple lysines in its C terminus, disrupting the association with Bax, which on release transits to the mitochondria and initiates apoptosis (Cohen et al., 2004a).”
Anticancer activities of histone deacetylase inhibitors (2006, background): “For example, the DNA end-joining protein Ku70 binds to and sequesters Bax in the cytoplasm and acetylation of Ku70 in response to HDACi releases Bax to translocate to the mitochondrial outer membrane to initiate apoptosi”
Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Moreover, Ku70, an important regulator of DNA-PK, is acetylated (Cohen et al., 2004).”
Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “Thus, many research efforts have been devoted to improve RNA interference (RNAi) therapeutics, which lead to important advances in the field [262, 263].”
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007, methodology): “We do not rule out the possibility that other known substrates of SIRT1 are involved, such as Ku70, a protein that sequesters the apoptotic protein Bax from mitochondria (Brunet et al, 2004; Cohen et al, 2004a).”