Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus.

By R. Dorschner, V. Pestonjamasp, Seema Tamakuwala, T. Ohtake, Jennifer A. Rudisill, V. Nizet, B. Agerberth, G. Gudmundsson, R. Gallo. Journal of Investigative Dermatology, 2001

603 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/323598c585c91886fc59c91c5be28d199f0946cd

How researchers see this paper

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In Microbiology

1. Robert E. W. Hancock
2. H. Jenssen
3. P. Hamill
4. M. Zanetti
5. A. Ramamoorthy
6. K. Brown
7. M. Tomic‐Canic

In Molecular Biology

1. Robert E. W. Hancock
2. H. Jenssen
3. M. Tomic‐Canic
4. M. Zanetti

Citations in the corpus

• Cationic host defense (antimicrobial) peptides. (2006, background): “The expression of cathelicidins (LL-37 and mouse cathelicidin-related antimicrobial peptide [CRAMP]) in skin keratinocytes varies with infection and/or injury [32].”
• Epithelialization in Wound Healing: A Comprehensive Review (2014, background): “Following wounding and/or microbial challenge, keratinocytes are also stimulated to release antimicrobial peptides (AMPs), including human cathelicidins, hCAP 18 and LL-37, and human b-defensins.(132) Ubiquitous in nature, AMPs are potent antimicrobial agents that are effective against both gram-pos”
• LL-37, the only human member of the cathelicidin family of antimicrobial peptides. (2006, background): “Gram negative bacteria Escherichia coli N32 μM [116] Pseudomonas aeruginosa 16 μg/ml [82] Actinobacillus actinomycetemcomitans 10 μg/ml [109] Salmonella typhimurium 3.”
• Peptide Antimicrobial Agents (2006, background): “LL-37 includes its upregulation in response to infection in the skin (54), as well as conditions in which a deficiency of LL-37 leads to chronic periodontal disease (204).”
• Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “In this respect, it is worth noting that CRAMP and LL-37 are structurally similar and, in addition, both are induced in the skin following skin injury and both are active against group A Streptococcus [82].”