Folate-mediated delivery of macromolecular anticancer therapeutic agents.

By Y. Lu, P. Low. Advanced Drug Delivery Reviews, 2002

971 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/32257fe998d385a38c6e02ae7c8a133337f88aa5

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In Biomaterials

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In Rheumatology

Vladimir Torchilin

Citations in the corpus

Current status of polymeric gene delivery systems. (2006, background): “The receptor is up-regulated and overexpressed in a number of rapidly growing malignant tumor cells, resulting in a dramatic promotion of the cellular uptake of folate [30].”
Recent advances with liposomes as pharmaceutical carriers (2005, background): “into living cells using FR endocytosis, which could bypass multidrug resistance, interest in folate-targeted drug delivery by liposomes grew rapidly (for important reviews see Ref”
Assessment of the Evolution of Cancer Treatment Therapies (2011, background): “The rationale for coupling these carriers with folic acid is that the folate receptor is over-expressed in a broad range of tumor cell types, including solid and hematological malignancies [57].”
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “These constructs have been shown to deliver DNA and RNA to specific target tissues, such as hepatocytes [86,137–140] and dendritic cells [139,140] via carbohydrates; tumor tissue via folate receptor [141], integrin [87] or transferrin [102] targeting; and to tissues expressing specific receptors wit”
Lipid-based Nanoparticles for Nucleic Acid Delivery (2007, background): “It targets the DNAcontaining particles to cancer cells that over-express the folate receptor (39).”
Endocytic mechanisms for targeted drug delivery. (2007, background): “With this in mind, drug delivery vehicles have been conjugated to high affinity targeting agents directed at specific cell surface receptors in cancer tissues including liver, breast, and brain [5].”
Viruses and their uses in nanotechnology (2006, background): “It appears that 15 to 25% of folate is released inside of the cells and the remainder is recycled to the cell surface [Lu and Low, 2002].”