Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.
By Brett C Dinatale, I. Murray, J. Schroeder, Colin A. Flaveny, T. Lahoti, E. Laurenzana, C. Omiecinski, G. Perdew. Toxicological Sciences, 2010
616 citations recorded by the source corpus.
Subfields: Biological Psychiatry, Health, Toxicology and Mutagenesis, Immunology
View Paper: https://www.semanticscholar.org/paper/321bb03c7588195ca23370eff27111bbed88f7df
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Citations in the corpus
- Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health (2017, background): “The expression of IDO and KATs allow Trp to be metabolized to Kyna, a GPR35 agonist (13) and a ligand for the transcription factor aryl hydrocarbon receptor (AhR) (similar activity has been shown for Kyn) (14, 15).”
- Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (2011, background): “More recently, Perdew and coworkers (DiNatale et al., 2010; Flaveny and Perdew, 2009; Schroeder et al., 2010) demonstrated that the human AhR exhibited a significantly higher ligand-binding affinity and responsiveness to a variety of natural and putative endogenous ligands (i.”