Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.

By J. James, P. Cutler, S. Melnyk, S. Jernigan, L. Janak, D. Gaylor, James A Neubrander. American Journal of Clinical Nutrition, 2004

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Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder (2008, background): “…have been identified in brains of individuals with autism (Vargas, Nascimbene, Krishman, Zimmerman, & Pardo, 2005) and markers of inflammation and oxidative stress have also been identified in blood and urine of individuals with autism (e.g., Ashwood & Van de Water, 2004; James et al., 2004).”
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006, methodology): “In a recent case-control study, we measured fasting levels of plasma methionine transmethylation and transsulfuration metabolites in 20 autistic and 33 control children [James et al., 2004].”
The changing faces of glutathione, a cellular protagonist. (2003, background): “This is the case of several psychiatric disorders, like schizophrenia (Regland et al., 1994; Yao et al., 2006), bipolar disorder (Frey et al., 2007; Kuratomi et al., 2008), and autism (James et al., 2004, 2006) which underscores the role of GSH and DNA methylation in these diseases.”
Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics (2018, background): “Advances in metabolic proﬁling have led to discoveries of biomarkers in a variety of medical conditions using metabolomics and lipidomics approaches, including the vision to utilize metabolomics for precision medicine [1–3].”