What are Biomarkers?
By K. Strimbu, J. Tavel. Current Opinion in HIV and AIDS, 2010
1,865 citations recorded by the source corpus.
Purpose of reviewThis article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research. Recent findingsThe definitions of the terms discussed in this article – medical signs, symptoms, biomarkers, surrogate endpoints, clinical endpoints, validation – are still under discussion, as are their relationships to each other, but broad consensus has developed in the past decade and a half about the necessity of distinguishing between, in particular, surrogate and clinical endpoints. SummaryThis article outlines the major definitions of the key terms in this field and considers select cases in which misunderstandings about the terms led to flawed research conclusions.
Subfields: Economics and Econometrics, Geriatrics and Gerontology, Oncology
View Paper: https://www.semanticscholar.org/paper/31e6198c63ab437922fad57f527bc500f7e4a803
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In Economics and Econometrics
- Mike Clarke
- S. Brookes
- Jane M. Blazeby
- C. Prinsen
- Douglas G. Altman
- C. Terwee
- David Moher
- K. F. Schulz
In Oncology
Citations in the corpus
- Extracting Possibly Representative COVID-19 Biomarkers from X-ray Images with Deep Learning Approach and Image Data Related to Pulmonary Diseases (2020, neutral): “rejected by the automatic classification performed after the convolutional layers of a CNN. The biomarkers are quantitative markers of confirmed significance and are not limited to the image features [23]. Generally, the ability of Deep Learning for biomarker extraction is questionable due to the is”
- Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “For instance, the 2-tailed formulations (high and low biomarker distributions) need to be more restrictive than the traditional 1-tailed quartile cut-points, although they might in turn have a less sensitive threshold and therefore limited ability to be used as an early warning signal of health and ”
- The COMET Handbook: version 1.0 (2017, background): “Examples of biomarkers include everything from pulse and blood pressure through basic chemistries to more complex laboratory tests of blood and other tissues [11].”