Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS

By Maureen P. Martin, Xiaojiang Gao, Jeong-Hee Lee, George W. Nelson, R. Detels, J. Goedert, S. Buchbinder, K. Hoots, D. Vlahov, J. Trowsdale and 3 more. Nature Genetics, 2002

1,275 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/31a827b5eb17c71eabd1cee0dcd98811e2f3b74e

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In Immunology

In Virology

Steven G. Deeks

Citations in the corpus

Natural killer cells act as rheostats modulating anti-viral T cells (2011, neutral): “Recent genetic evidence, however, has indicated a correlation between certain natural killer (NK)-cell receptors and progression of both HIV and HCV infectio”
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success (2004, background): “In infectious disease, such as HIV, acquisition of activating KIR‐HLA combinations has also been shown to be advantageous ( 42 ).”
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA (2004, background): “Moreover, data describing the epistatic interaction between KIR3DS1 and HLA-B indicated that HLA-Ba57- and Ba27-mediated protection was entirely independent of this interactio”
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, background): “Indeed, we have previously shown that the activating KIR3DS1 allele in combination with Bw4-80I associates with protection against HIV disease progressio”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Genetic studies have revealed that certain activating KIRs, in combination with specific MHC-I ligands, may provide protection from progression to AIDS in HIV-infected individuals (29) and from preeclampsia in pregnant mothers (30).”