Resolution of inflammation: an integrated view

By A. Ortega-Gómez, M. Perretti, Oliver Soehnlein. EMBO Molecular Medicine, 2013

691 citations recorded by the source corpus.

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3106f89c16c72fc2aa7c96fcdc2af5874041ba28

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In Immunology

Citations in the corpus

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities (2018, background): “, lipoxins and resolvins), annexin A1, and lactoferrin, act to prevent neutrophil transmigration and entry, and promote neutrophil apoptosis and the phagocytic uptake of apoptotic neutrophils by macrophages (Ortega-Gomez et al., 2013).”
Inflammation, Fracture and Bone Repair (2016, background): “If this does not occur, permanent tissue alterations may result due to ongoing active inflammation, fibrosis, or chronic inflammation, in which active inflammation, fibrosis and attempts at repair all occur simultaneously [12].”
Microglial M1/M2 polarization and metabolic states (2016, background): “IL-10, IL-13, TGF-β), VEGF, EGF, Arg1) to deactivate pro-inflammatory cell phenotypes and re-establish homeostasis (Gordon, 2003; Gordon and Martinez, 2010; Ortega-Gómez et al., 2013).”
Low-grade inflammation, diet composition and health: current research evidence and its translation (2015, neutral): “inflammatory properties of flavonoids include (1) an inhibitory role in the release of cytokines, such as IL-1b and TNF-a, from activated microglia; (2) an inhibitory action against inducible NO synthase induction and subsequent NO production in response to glial activation; (3) an ability to inhibi”
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype (2016, background): “In acute inflammation, neutrophils are not only vital for clearing the wound from pathogens or debris but also for the resolution of inflammation and return to tissue homeostasis.(9) In the context of MI, however, neutrophils are generally considered detrimental.”
Producing Omega-3 Polyunsaturated Fatty Acids: A Review of Sustainable Sources and Future Trends for the EPA and DHA Market (2020, background): “Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) are the main precursors to produce specialized proresolving mediators (SPMs) known as resolvins, maresins and protectins, inhibiting the synthesis of proinflammatory cytokines [13,14].”