Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

By M. Horckmans, L. Ring, J. Duchêne, D. Santovito, M. Schloss, Maik Drechsler, Christian Weber, Oliver Soehnlein, S. Steffens. European Heart Journal, 2016

714 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/ff526ae56ab07a2661a86fdb2dc993c4cae6109f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Sumanth D. Prabhu
2. Nikolaos G. Frangogiannis

In Immunology

1. Sumanth D. Prabhu
2. Nikolaos G. Frangogiannis

In Surgery

1. Sumanth D. Prabhu
2. Nikolaos G. Frangogiannis

Citations in the corpus

• The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. (2016, background): “A recent study demonstrated that neutrophils, via secreted neutrophil gelatinase-associated lipocalin, polarize macrophages toward a reparative phenotype, thereby orchestrating tissue healing (Figure 4).(171) Monocytes, macrophages, and DCs: After the early appearance of neutrophils, monocytes and m”
• Cellular and molecular mechanisms of skin wound healing (2024, neutral): “One of the key triggers for this phenotype switch in wound macrophages towards pro-resolving functions may be their efferocytosis of spent neutrophils 116,117 , which also promotes the production and secretion of lipoxins by macrophages, promoting resolution of inflammation 118 .”