Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

By C. Rada, G. Williams, H. Nilsen, D. Barnes, Tomas Lindahl, M. Neuberger. Current Biology, 2002

752 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30c337e673d8e96a0350f60f4b601fe060b9ed04

How researchers see this paper

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In Immunology

1. Theam Soon Lim

In Molecular Biology

1. P. Pham
2. R. Bransteitter
3. J. Petruska
4. Theam Soon Lim
5. Myron F. Goodman

Citations in the corpus

• Mechanism and regulation of class switch recombination. (2008, background): “Two other uracil glycosylases (MBD4 and SMUG1) appear to have no role in CSR (38, 63).”
• Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation (2003, background): “These deamination results on ssDNA bear relevance to three characteristic features of SHM: preferential mutation at C sites within WR C hotspot sequences, the broad clonal mutagenic heterogeneity of antibody variable regions targeted for mutatio”
• Naïve Human Antibody Libraries for Infectious Diseases (2018, background): “Antibodies that have undergone SHM will produce higher affinity antigen receptors to compete with lower affinity or inactive antibodies.”