Function and genetics of dystrophin and dystrophin-related proteins in muscle.

By D. Blake, Andrew P. Weir, S. Newey, K. Davies. Physiological Reviews, 2002

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Cerebellar Synaptic Defects and Abnormal Motor Behavior in Mice Lacking α- and β-Dystrobrevin (2006, background): “The integrity of skeletal muscle fibers is maintained in part by a multi-molecular, transmembrane protein complex called the dystrophin– glycoprotein complex (DGC) that links the cytoskeleton to the extracellular matrix (Ervasti and Campbell, 1991) (for review, see Blake et al., 2002).”
Striated muscle cytoarchitecture: an intricate web of form and function. (2002, background): “Syntrophin directly binds bothα-dystrobrevin and dystrophin, and its C-terminal PDZ-domain associates with neuronal-type nitric oxide synthase (nNOS) (Blake et al. 2002).”
Cell and Molecular Biology (2009, background): “Dystrophin is associated with the sarcolemma, as part of a large complex of transmembrane proteins named the dystrophin-associated protein complex (Blake et al., 2002).”
Efficient TALEN-mediated gene knockout in livestock (2012, background): “1 because a high percentage of Duchene’s Muscular Dystrophy (DMD) is caused by gross deletions (25), providing the opportunity to mimic the human condition in a porcine model.”