HMG-1 as a mediator of acute lung inflammation.

By E. Abraham, J. Arcaroli, A. Carmody, Haichao Wang, Kevin J. Tracey. Journal of Immunology, 2000

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High mobility group box 1 protein interacts with multiple Toll-like receptors. (2006, background): “organization, migration, and release of proinflammatory cytokines (1, 2, 9, 32).”
Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones (2012, methodology): “Control mice were treated with PBS only [35–37].”
DAMPening Inflammation by Modulating TLR Signalling (2010, background): “Lung inflammation (LPS) pAb decreased neutrophils, lung edema [136, 138]”
HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection (2011, background): “Respiratory disorders Neutralizing polyclonal anti-HMGB1 antibodies (60, 61, 64, 67, 132)”
HMGB1: Endogenous Danger Signaling (2008, background): “However, HMGB1 also is secreted actively by immune cells such as monocytes, macrophages, and dendritic cells (10,16,26).”
Cytokine-mediated inflammation in acute lung injury. (2003, background): “HMG-1 given intratracheally to animals produces an acute inflammatory injury to the lungs[52].”