Leukocytes navigate by compass: roles of PI3Kγ and its lipid products

By P. Rickert, O. Weiner, Fei Wang, H. Bourne, G. Servant. 2000

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Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice (2004, background): “Several studies have shown that lipid products of PI3Kg play a role as ‘compass’ molecules by controlling the direc- tion of cell migration and the intracellular localization of F-actin and signalling molecules at the leading edge (Rickert et al, 2000).”
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. (2002, background): “We at the leading edge and localized accumulation of PI3K demonstrate that while phosphatidylinositol 3-kinase products, resulting in the recruitment of a subset of PH (PI3K) transiently translocates to the plasma memdomain-containing proteins and activation of effector brane in response to chemoatt”
Rho GTPases and cell migration. (2001, background): “How does Rac get activated? Rac activation by both tyrosine kinases and G-protein-coupled receptors is often dependent on phosphoinositide 3-kinase (PI 3-kinase) activity, and inhibitors of PI 3-kinase block Rac activation (Sander et al., 1998; Rickert et al., 2000; Royal et al., 2000).”