Alternative activation of macrophages: an immunologic functional perspective.

By F. Martínez, L. Helming, S. Gordon. Annual Review of Immunology, 2009

2,812 citations recorded by the source corpus.

Subfields: Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/305c4eba520a743b0476994fc45125bca3c1af3e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. F. Martínez
5. S. Gordon
6. R. Locksley
7. J. Joyce
8. A. Chawla

In Parasitology

1. A. Mantovani
2. A. Sica
3. R. Locksley
4. S. V. Van Dyken
5. S. Pun
6. Heather H Gustafson
7. Chayanon Ngambenjawong

Citations in the corpus

• INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “Consequently, although gene profiling studies have yielded additional markers to verify (34--37), these caveats caution against the exclusive use of any single marker in establishing the AAM phenotype; rather, a combinatorial approach should be employed in parallel with an assessment of contribution”
• Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “Moreover, pathology is frequently associated with dynamic changes in macrophage activation, with classically activated M1 cells implicated in initiating and sustaining inflammation and M2 or M2-like cells associated with resolution or smoldering chronic inflammation (9).”
• The M1 and M2 paradigm of macrophage activation: time for reassessment (2014, background): “In IL-4 KO animals, the numbers of macrophages andmaturation are normal, and defects appear in the immune response against nematodes and some viral infections; for recent reviews, see [42,43].”
• Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages (2019, background): “In vitro alternatively activated macrophages have been shown to produce all these chemokines in high amounts in the response of Th2 cytokines such as IL-4, and IL-13 (18, 79).”
• Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “These cells have a unique anti-inflammatory signature (IL-10 high, IL-12 low, IL-6 high, and TNF-a low) and are distinct from monocyte derived M2 macrophages, due to their increased production of IL-6 [85].”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “IFNγ polarized macrophages are called M1 or 'classically' activated macrophages, whereas IL-4 and IL-13 polarized macrophages are termed M2 or 'alternatively activated' macrophage”
• Novel Markers to Delineate Murine M1 and M2 Macrophages (2015, background): “While in vivomacrophage characterization is complex and varied over a spectrum of phenotypes [3,9,10], in vitromodels provide a snapshot of phenotype extremes.”
• CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models (2014, positive): “classical activation of macrophages can restrain cancer development, alternative activation often plays a protumorigenic role (28, 29).”
• CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 (2011, positive): “Macrophages are heterogeneous cells that respond differently to various microenvironmental signals and, thus, display distinct functions (Gordon, 2003; Martinez et al., 2009).”