Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.

By L. Samelson. Annual Review of Immunology, 2002

648 citations recorded by the source corpus.

Engagement of the T cell antigen receptor (TCR) leads to a complex series of molecular changes at the plasma membrane, in the cytoplasm, and at the nucleus that lead ultimately to T cell effector function. Activation at the TCR of a set of protein tyrosine kinases (PTKs) is an early event in this process. This chapter reviews some of the critical substrates of these PTKs, the adapter proteins that, following phosphorylation on tyrosine residues, serve as binding sites for many of the critical effector enzymes and other adapter proteins required for T cell activation. The role of these adapters in binding various proteins, the interaction of adapters with plasma membrane microdomains, and the function of adapter proteins in control of the cytoskeleton are discussed.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30397d3f50b79668d626b423080ca9198e65a42a

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Citations in the corpus

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation (2009, background): “Published work has shown that a key intermediary between the TCR-CD3 complex and Lat is Zap70, which binds phosphorylated immunoreceptor tyrosine-based activation motifs on CD3 molecules when the TCR has engaged a ligand, becomes activated by Lck and then phosphorylates La”
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies (2002, methodology): “Signaling pathways activated after engagement of the T cell antigen receptor (TCR)* have been studied using biochemical techniques for over a decade (for review see Koretzky and Myung, 2001; Yablonski and Weiss, 2001; Samelson, 2002).”
CD28-mediated co-stimulation: a quantitative support for TCR signalling (2003, background): “The TCR signals its ligation through IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS (ITAMs) that are present in ten copies distributed among its six CD3-ζ subunit”
Mechanism of B-Cell Receptor-Induced Phosphorylation and Activation of Phospholipase C-γ2 (2004, background): “Rather, various adapter proteins provide a platform for such an interaction (23, 28, 36).”
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling (2007, background): “The adaptor protein Grb2 contains a along concentrations schedule adaptor protein LAT, which is rapidly phosphorylated at multiple problematic sites after TCR activation (Samelson 2002).”
Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005, background): “Second, we have omitted explicit specification of a number of molecules that are well documented in the literature to affect T-cell signaling responses, such as CD45, Csk, and several adapter proteins [63,64].”
A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach (2008, methodology): “We also tested the ability of MHC class II binding prediction methods to predict a peptide's ability to activate CD4+ T cells. Most of the methods were associated with good performance. This was somewhat surprising since T cell activation is a multi-step process where multiple signals are needed for”
Jurkat T cells and development of the T-cell receptor signalling paradigm (2004, neutral): “cgi?l=7409">VAV1 , during TCR-dependent T-cell activatio”
The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells1 (2006, background): “T he TCR signaling cascade is initiated by tyrosine kinases that regulate the assembly of a complex of adapter proteins and other signaling molecules (1, 2).”
Recruitment and activation of PLCγ1 in T cells: a new insight into old domains (2006, background): “Proximal events that immediately follow TCR engagement include activation of protein kinases and phosphorylation of multiple enzymes and adaptor molecules (Burack et al, 2002; Samelson, 2002).”
CD28 and CTLA-4 coreceptor expression and signal transduction (2009, background): “Micro-clustering of kinases and adapters is needed for effective transmission of signals from the TCR complex (30).”