Centrosome polarization delivers secretory granules to the immunological synapse

By J. Stinchcombe, E. Majorovits, G. Bossi, S. Fuller, G. Griffiths. Nature, 2006

672 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Lysosomes: fusion and function (2007, background): “Following recognition of a foreign antigen, the lymphocyte centrosome polarizes towards the target cell and makes contact with the inside of the lymphocyte plasma membran”
Formation and function of the lytic NK-cell immunological synapse (2008, background): “Recently however, the MTOC in CTLs was shown to associate closely with the synapse and to directly deliver the lytic granules, without the need of additional plus-ended granule motility along individual microtubule”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “In the case of cytotoxic T lymphocytes (CTLs), for example, the centrosome migrates to the site of contact between the CTL and its target cell, where it helps deliver the lytic granules that will ultimately kill the target cell (Stinchcombe et al., 2006).”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “Polarized lytic granules travel along microtubules and, once at the IS, fuse with the target cell membrane and release enzymes that facilitate that activation of the intrinsic apoptosis program within the target cell (136, 151).”