Inaugural Article: Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae

By J. Gerton, J. Derisi, R. Shroff, M. Lichten, Patrick O. Brown, T. D. Petes. 2000

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Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex (2001, background): “In yeast, meiotic crossovers also cluster into hot spots that tend to associate with GC-rich chromosomal domain”
Meiotic Recombination: The Essence of Heredity. (2015, background): “Detection of recombination intermediates by Southern analysis was dependent on the fact that DSBs at the assayed loci were confined to very narrow regions or hotspots, a conserved feature that was subsequently shown to apply genome-wide and has been the subject of intense studies (e.g., Baudat and N”
Recombination proteins in yeast. (2004, background): “The sites of DSBs coincide with DNase I hypersensitive sites in chromatin and are generally in the 5′ noncoding regions of genes (17, 65, 232).”
ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. (2004, background): “Other applications have been reported, including the study of DNA replication [34], recombination [35], and chromatin structure [23–25,36].”
Genome-Wide Mapping of the Cohesin Complex in the Yeast Saccharomyces cerevisiae (2004, unknown): “The genome-wide distribution of DSBs is positively correlated with regions of high GC content, divergent promoters, and transcription factor binding (Gerton et al. 2000).”