All-or-none potentiation at CA3-CA1 synapses.

By Carl C. H. Petersen, R. Malenka, R. Nicoll, John J. Hopfield. 1998

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression (2008, methodology): “While there is evidence for switch like transitions during the induction of E-LTP and E-LTD [7, 37 ], the bistability of the late phase of synaptic plasticity has so far not been shown.”
Phenomenological models of synaptic plasticity based on spike timing (2008, background): “At a first glance, this seems to be at odds with experimental data suggesting that single synaptic contacts are in fact binary (Petersen et al. 1998; O’Connor et al. 2005).”
Spike Timing Dependent Plasticity: A Consequence of More Fundamental Learning Rules (2010, unknown): “However, the induction of plasticity appears experimentally to be sudden and discrete, and possibly even a two-state system of binary strength (Petersen et al., 1998; O’Connor et al., 2005b).”
Statistical mechanics of complex neural systems and high dimensional data (2013, background): “However, what if synaptic weights cannot take arbitrary analog values? Indeed, evidence suggests that biological synapses behave like noisy binary switches [88, 89], and thus can reliably code only two levels of synaptic weights, rather than a continuum.”
A VLSI array of low-power spiking neurons and bistable synapses with spike-timing dependent plasticity (2006, result): “These assumptions are compatible with experimental data [37] and are supported by experimental evidence [43].”
Synaptic Consolidation: From Synapses to Behavioral Modeling (2015, background): “First, minimal LTP stimulation protocols indicate that changes in the amplitude of the postsynaptic current (PSC) or postsynaptic potential (PSP) are visible already a few seconds after the induction protocol (Petersen et al., 1998; O’Connor et al., 2005).”
Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location (2012, methodology): “Slow dynamics after the induction protocol are seen in many experiments (3, 6, 10) but not experiments involving putative single synaptic connections (29, 31) that are consistent with abrupt changes between two discrete states.”
Learning Real-World Stimuli in a Neural Network with Spike-Driven Synaptic Dynamics (2007, background): “Not only is there accumulating evidence that biological single synaptic contacts undergo all-or-none modifications ( Petersen, Malenka, Nicoll, & Hopfield, 1998; Wang, O’Connor, & Wittenberg, 2004), but additional synaptic states do not significantly improve the memory performance (Amit & Fusi, 199”