Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.

By J. Hampe, A. Cuthbert, P. Croucher, M. Mirza, S. Mascheretti, S. Fisher, Henning Frenzel, K. King, Anja Hasselmeyer, Andrew J. Macpherson and 10 more. The Lancet, 2001

1,135 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/2f60d0ce83ceaff2ceecc37bd018f2f340998965

How researchers see this paper

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In Epidemiology

1. J. Colombel
2. S. Lesage
3. June L. Round
4. W. Strober
5. S. Mazmanian

In Genetics

1. S. Rosenberg
2. J. Colombel
3. DM Mosser
4. X. Zhang
5. June L. Round
6. W. Strober
7. S. Mazmanian
8. Markus F. Neurath

In Surgery

1. S. Mazmanian

Citations in the corpus

• Macrophage activation by endogenous danger signals (2008, background): “Card15 mutations have been implicated in IBD pathogenesis [126].”
• Electrolyte transport in the mammalian colon: mechanisms and implications for disease. (2002, background): “In that respect, CD was shown to be linked to a mutation in the NOD2 gene, but not UC (250, 278).”
• Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. (2006, background): “Recent data have implicated polymorphisms in the CARD15/NOD2 gene, as well as antibody responses to bacterial antigens as risk factors in developing inflammatory bowel disease.(23-25) These factors and known polymorphisms in the CTLA4 gene are currently being investigated in our patients to determin”
• The immunological and genetic basis of inflammatory bowel disease (2003, background): “, it was shown that the 3020 insertion in the NOD2 gene is present both in familial and sporadic cases of Crohn's disease and that homozygosity for this mutation was not found in normal individual”
• The gut microbiome shapes intestinal immune responses during health and disease (2009, positive): “These include disease-associated mutations in genes that are involved in bacterial sensing (such as NOD2 (nucleotide-binding oligomerization domain 2; also known as CARD15 )”