25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

By N. Annabi, Ali Tamayol, J. Uquillas, Mohsen Akbari, L. Bertassoni, Chaenyung Cha, Gulden Camci‐Unal, Mehmet Remzi Dokmeci, Nicholas A. Peppas, Ali Khademhosseini. Advances in Materials, 2013

1,228 citations recorded by the source corpus.

Hydrogels are hydrophilic polymer‐based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three‐dimensional (3D) matrices for tissue engineering, drug‐delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life.

Subfields: Biomaterials, Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/2ef636efc75970d5c897de1924f16464319340cc

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Citations in the corpus

The shape – morphing performance of magnetoactive soft materials (2021, background): “For a wide range of works focused on these multifunctional materials, we refer to [29,38,106,107,111-117].”
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Drug Delivery Systems and Materials for Wound Healing Applications (2018, neutral): “Hydrogel scaffolds—Hydrogels are promising materials for designing scaffolds that promote wound healing [7, 74].”
Microfluidic Devices for Drug Delivery Systems and Drug Screening (2018, methodology): “There are several strategies to form non‐spherical delivery systems in different sizes and shapes by microfluidic channels, including self‐assembly of spherical building blocks, stretching and deforming droplets before or during solidification in the confined channels, or by flow lithogra”