Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

By K. Yue, G. Santiago, M. M. Álvarez, Ali Tamayol, N. Annabi, Ali Khademhosseini. Biomaterials, 2015

2,688 citations recorded by the source corpus.

Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/db0131b27b7eaf183c929a73ccd69d06de5cc188

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Citations in the corpus

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip (2016, neutral): “S1B and C), likely due to the degradation of the GelMA and thus impaired integrity of the mic rofibrous structures [56, 57].”
An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects (2018, positive): “It offers a fast and accurate fabrication, with resolutions ranging between 5–300 μm [61,62].”
Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms (2016, methodology): “Instead, we suggest using the term ‘gelatin methacryloyl’ to reflect the coexistence of both methacrylamide and methacrylate groups in GelMA 38 .”