Nanocomposite hydrogels for biomedical applications

By A. Gaharwar, Nicholas A. Peppas, Ali Khademhosseini. Biotechnology and Bioengineering, 2013

1,080 citations recorded by the source corpus.

Hydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon-based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydrogel networks to obtain nanocomposites with superior properties and tailored functionality. Nanocomposite hydrogels can be engineered to possess superior physical, chemical, electrical, and biological properties. This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications. In particular, we discuss synthesis and fabrication of nanocomposite hydrogels, examine their current limitations and conclude with future directions in designing more advanced nanocomposite hydrogels for biomedical and biotechnological applications.

Subfields: Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/2d9234c3c32427193b05e326fcc384f5866e275d

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In Biomedical Engineering

In Molecular Medicine

A. Gaharwar

Citations in the corpus

Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery. (2015, background): “Polymeric nanoparticles such as hyper-branched polymers, liposomes, micelles, microspheres, and cyclodextrins, which are widely used as drug delivery systems, have also been incorporated into hydrogels to utilize their drug releasing ability, as well as to improve their mechanical properties.(9) For”