Id proteins in development, cell cycle and cancer.

By M. Ruzinova, R. Benezra. Trends in Cell Biology, 2003

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Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008, background): “Expression of several of the Id proteins has been associated with tumour progression and several genetic studies suggest that the presence of Id factors is necessary for tumour vascularization through regulation of pro-angiogenic factor”
G1 cell-cycle control and cancer (2004, background): “This role partly falls on members of the ID family (ID1 to 4”
Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “The Id proteins represent a family of naturally occurring inhibitors of basic helix–loop–helix transcription (bHLH) factors, and function in many circumstances to prevent differentiation (Ruzinova and Benezra 2003).”
TGFβ in Cancer (2008, background): “TGFβ also modulates differentiation through the regulation of Id proteins (Inhibitor of Differentiation/DNA binding) that negatively regulate cell differentiation by interfering with prodifferentiation bHLH transcription factors (Ruzinova and Benezra, 2003).”