Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

By G. Boden, Gerald I. Shulman. European Journal of Clinical Investigation, 2002

1,031 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/2eb09abb17cda5614520819d810e731f97440747

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Citations in the corpus

Endothelial dysfunction in diabetes mellitus (2007, neutral): “Insulin resistance is closely linked with visceral adiposity, and early data suggested that free fatty acids were responsible for this association (Boden and Shulman 2002).”
Insulin Resistance, Hyperglycemia, and Atherosclerosis (2011, neutral): “Another characteristic of insulin-resistant states is elevated levels of free fatty acids (Boden and Shulman, 2002).”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “It should be noted that the same scenario would ensue if the FFA were derived from triglycerides stored in muscle (34, 35) or from plasma (21, 28, 29).”
beta-cell failure in diabetes and preservation by clinical treatment. (2007, background): “Regarding GLP-1, DPP-IV activation results in the inactivation of GLP-1 (7-36) amide and the generation of the metabolite GLP-1 (9-36) amide, which did not activate the GLP-1 receptor, thus not enhancing the insulin secretion and not blocking GLP-1 (7-36) amide enhancement of insulin secretion durin”
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. (2007, background): “Many studies investigating acute effects of lipids on insulin action have involved the infusion of Intralipid or Liposyn II (Boden and Shulman, 2002; Kim et al., 2004; Kim et al., 2001; Kim et al., 2002; Yu et al., 2002), which are soy-based lipid cocktails enriched in the unsaturated fat linoleate…”