Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

By J. Talon, C. Horvath, R. Polley, C. Basler, T. Muster, P. Palese, A. García‐Sastre. Journal of Virology, 2000

643 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/2e321f982b5f325296f9c4eecbfd323c938a0053

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. García‐Sastre
2. P. Palese
3. M. Gale
4. Jae U. Jung
5. R. Randall
6. S. Goodbourn
7. Shizuo Akira
8. J. Taubenberger

In Immunology

1. R. Randall
2. A. García‐Sastre
3. Y. Loo
4. S. Goodbourn
5. P. Palese
6. L. Martínez-Sobrido
7. M. Gale
8. Shizuo Akira

In Oncology

1. M. Gale
2. R. Randall
3. S. Goodbourn
4. Y. Loo
5. Shizuo Akira

Citations in the corpus

• The multifunctional NS1 protein of influenza A viruses. (2008, methodology): “However, a benefit of NS1-truncated viruses is that they are likely to display increased genetic stability (Falcon et al., 2005; Ferko et al., 2004; Quinlivan et al., 2005; Richt et al., 2006; Talon et al., 2000b).”
• Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists (2006, methodology): “(pHISG54-GFP/CAT) plasmids were described previously (12, 15, 20, 25).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “…this domain may be to mop up dsRNA to prevent activation of OAS (Min & Krug, 2006), depending on the virus strain (Hayman et al., 2006; Kochs et al., 2007), it may also play an important role in preventing dsRNA-mediated induction of IFN (Talon et al., 2000a; Wang et al., 2000; Li et al., 2006b).”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, neutral): “…pleiotropic since it not only binds to and sequesters dsRNA molecules to prevent induction of IFNs (Garcia-Sastre, 2001; Garcia-Sastre et al., 1998; Talon et al., 2000a; Wang et al., 2000) but also inhibits the 3V end processing of cellular pre-mRNAs, regulates the virus replica- tion cycle and…”
• Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon (2000, methodology): “Critical transcription factors which have been shown to be involved in regulating IFN-b transcription include IRF-3, AP1, and NF-kB.”
• Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “by inhibiting activation of IRF-3 (Talon et al., 2000), NF-kB (Wang et al.”
• Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus (2006, background): “The NS1 protein antagonizes both the induction of IFN- (49) and the activity of PKR and OAS, IFN-induced proteins with antiviral activities (5, 27, 38).”