Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon

By Xiuyan Wang, Ming Li, Hongyong Zheng, T. Muster, P. Palese, A. Beg, A. García‐Sastre. Journal of Virology, 2000

604 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cc1647c36896377ea12fa3a6eec8410d8e509770

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In Immunology

1. R. Randall
2. S. Goodbourn
3. A. García‐Sastre
4. F. Weber
5. J. Rehwinkel
6. C. Reis e Sousa
7. D. Goubau
8. Shizuo Akira

In Molecular Biology

1. F. Weber
2. J. Rehwinkel
3. R. Randall
4. S. Goodbourn
5. C. Reis e Sousa
6. D. Goubau
7. Shizuo Akira

Citations in the corpus

• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “…not only binds to and sequesters dsRNA molecules to prevent induction of IFNs (Garcia-Sastre, 2001; Garcia-Sastre et al., 1998; Talon et al., 2000a; Wang et al., 2000) but also inhibits the 3V end processing of cellular pre-mRNAs, regulates the virus replica- tion cycle and enhances translation…”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “, 2007), it may also play an important role in preventing dsRNA-mediated induction of IFN (Talon et al., 2000a; Wang et al., 2000; Li et al., 2006b).”
• The multifunctional NS1 protein of influenza A viruses. (2008, methodology): “Studies using PR8/NS1 demonstrated that this protein prevents dsRNA- and virus-mediated activation of the IRF-3, NFkB and c-Jun/ATF-2 transcription factors, which are otherwise essential for IFN-b induction (Ludwig et al., 2002; Talon et al., 2000a; Wang et al., 2000).”
• Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “, 2000), NFκB (Wang et al., 2000), and ATF-2/c-Jun (Ludwig et al.”
• RIG-I detects viral genomic RNA during negative-strand RNA virus infection. (2010, methodology): “To capture the physiologically relevant RIG-I agonist during SeV infection, we again made use of flu NS1, which is able to inhibit IFN responses to SeV (Wang et al., 2000).”